A tiered, Bayesian approach to estimating population variability for regulatory decision-making
نویسندگان
چکیده
منابع مشابه
A tiered, Bayesian approach to estimating of population variability for regulatory decision-making.
Characterizing human variability in susceptibility to chemical toxicity is a critical issue in regulatory decision-making, but is usually addressed by a default 10-fold safety/uncertainty factor. Feasibility of population-based in vitro experimental approaches to more accurately estimate human variability was demonstrated recently using a large (~1000) panel of lymphoblastoid cell lines. Howeve...
متن کاملA Tiered, Bayesian Approach to Estimating Population Variability for Regulatory Decision-Making
377 Received August 25, 2016; Accepted December 9, 2016; Epub December 13, 2016; doi:10.14573/altex.1608251 into account the genetic diversity within populations, overlooking uncertainties about how genetic variability might interact with environmental exposures to affect risk (Rusyn et al., 2010). As a result, while characterization of human variability in susceptibility to chemical toxicity i...
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هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...
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ژورنال
عنوان ژورنال: ALTEX
سال: 2017
ISSN: 1868-596X
DOI: 10.14573/altex.1608251